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This version was published on March
1, 2008
American Journal of Men's Health, Vol. 2, No. 1,
37-39 (2008)
DOI: 10.1177/1557988307308612
The Peripheral Serotonergic Pathway: A New Target for Treating Erectile Dysfunction?
David H. W. Lau, MSc
Department of Clinical Biochemistry, University College London, Department of Surgery Royal Free University College Medical School, University College London, London, UK
Cecil S. Thompson, PhD
Department of Clinical Biochemistry, University College London, Department of Surgery Royal Free University College Medical School, University College London, London, UK
Dimitri P. Mikhailidis, MD, FRCP, FRCPath
Department of Clinical Biochemistry, University College London, Department of Surgery Royal Free University College Medical School, University College London, London, UK, mikhailidis{at}aol.com
References
- Ahlenius, S., Larsson, K., & Arvidsson, L.E. (1989). Effects of stereoselective 5-HT1A agonists on male rat sexual behavior. Pharmacology, Biochemistry, and Behavior, 33, 691-695.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Ahn, G.J., Kang, K.K., Kim, D.S., Ahn, B.O., Kim, W.B., Kang, S.K., et al. (2005). DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats. Urology, 65, 202-207.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Angulo, J., Peiro, C., Sanchez-Ferrer, C.F., Gabancho, S., Cuevas, P., Gupta, S., et al. (2001). Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. British Journal of Pharmacology, 134, 1190-1194.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Bancila, M., Giuliano, F., Rampin, O., Mailly, P., Brisorgueil, M.J., Calas, A., et al. (2002). Evidence for a direct projection from the paraventricular nucleus of the hypothalamus to putative serotoninergic neurons of the nucleus paragigantocellularis involved in the control of erection in rats. European Journal of Neuroscience, 16, 1240-1248.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Bancila, M., Verge, D., Rampin, O., Backstrom, J.R., Sanders-Bush, E., McKenna, K.E., et al. (1999). 5-Hydroxytryptamine 2C receptors on spinal neurons controlling penile erection in the rat. Neuroscience, 92, 1523-1537.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Barradas, M.A., Gill, D.S., Fonseca, V.A., Mikhailidis, D.P., & Dandona, P. (1988). Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. European Journal of Clinical Investigation, 18, 399-404.[ISI][Medline]
[Order article via Infotrieve]
- Brotto, L.A., & Gorzalka, B.B. (2000). Melatonin enhances sexual behavior in the male rat. Physiology and Behavior, 68, 483-486.[CrossRef][Medline]
[Order article via Infotrieve]
- Esen, A.A., Gidener, S., Guler, C., Guven, H., & Kirkali, Z. (1997). Contractility changes of the deep dorsal penile vein due to serotonin. Journal of Urology, 158, 234-237.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Finberg, J.P., & Vardi, Y. (1990). Inhibitory effect of 5-Hydroxytryptamine on penile erectile function in the rat. British Journal of Pharmacology, 101, 698-702.[ISI][Medline]
[Order article via Infotrieve]
- Furukawa, K., Nagao, K., Ishii, N., & Uchiyama, T. (2003). Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit. International Journal of Impotence Research, 15, 267-271.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Giuliano, F. (2007). 5-Hydroxytryptamine in premature ejaculation: Opportunities for therapeutic intervention. Trends in Neuroscience, 30, 79-84.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Hayes, E.S., & Adaikan, P.G. (2002). The effects of 5HT(1) agonists on erection in rats in vivo and rabbit corpus cavernosum in vitro. International Journal of Impotence Research, 14, 205-212.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Hull, E.M., Muschamp, J.W., & Sato, S. (2004). Dopamine and serotonin: influences on male sexual behavior. Physiology and Behavior, 8, 291-307.[CrossRef]
- Kimura, Y., Naitou, Y., Wanibuchi, F., & Yamaguchi, T. (2006). Characterization of intracavernous pressure increase induced by Ym348, a novel 5-HT2C receptor agonist, in anesthetized rats. Journal of Urology, 175, 1953-1957.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Lau, D.H., Thompson, C.S., Bellringer, J.F., Thomas, P.J., Mumtaz, F.H., Morgan, R.J., et al. (2006). Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. Journal of Andrology, 27, 679-685.[Abstract/Free Full Text]
- Lau, D.H.W., Thompson, C.S., Mumtaz, F.H., Morgan, R.J., & Mikhailidis, D.P. (in press). Serotonin induces a biphasic response in rabbit cavernosal smooth muscle: Relevance to the erectile process. Urologia Internationalis, 79.
- Martin, G.R., & Humphrey, P.P. (1994). Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature. Neuropharmacology, 33, 261-273.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Myrick, H., Markowitz, J.S., & Henderson, S. (1998). Priapism following trazodone overdose with cocaine use. Annals of Clinical Psychology, 10, 81-83.[CrossRef]
- Rehman, J., Kaynan, A., Christ, G., Valcic, M., Maayani, S., & Melman, A. (1999). Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain Research, 821, 414-425.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Rothman, R.B., & Baumann, M.H. (2002). Serotonin releasing agents: neurochemical, therapeutic and adverse effects. Pharmacology, Biochemistry, and Behavior, 7, 825-836.
- Steers, W.D. (1990). Neural control of penile erection. Seminars in Urology, 8, 66-79.[Medline]
[Order article via Infotrieve]
- Uckert, S., Fuhlenriede, M.H., Becker, A.J., Stief, C.G., Scheller, F., Knapp, W.H., et al. (2003). Is serotonin significant for the control of penile flaccidity and detumescence in the human male? Urological Research, 31, 55-60.[ISI][Medline]
[Order article via Infotrieve]
- Vrentzos, G.E., Paraskevas, K.I., & Mikhailidis, D.P. (2007). Dyslipidemia as a risk factor for erectile dysfunction. Current Medicinal Chemistry, 14, 1689-1699.[CrossRef][ISI][Medline]
[Order article via Infotrieve]
- Waldinger, M.D. (2007). Premature ejaculation: Definition and drug treatment. Drug, 67, 547-568.[CrossRef][ISI][Medline]
[Order article via Infotrieve]

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