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This version was published on June 1, 2008
American Journal of Men's Health, Vol. 2, No. 2, 178-189 (2008)
DOI: 10.1177/1557988307313918

Prevention of Prostate Cancer: What We Know and Where We Are Going

Jayakrishnan Jayachandran, MD

Department of Surgery, Veterans Administration Medical Center Durham, Durham, North Carolina, jayakrishnan.jayachandran{at}duke.edu

Stephen J. Freedland, MD

Department of Surgery, Veterans Administration Medical Center Durham, Durham, North Carolina, Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, Department of Pathology, Duke University School of Medicine, Durham, North Carolina

As one of the most prevalent cancers, prostate cancer has enormous public health importance and its prevention seems to be a rational approach to attenuate the economic, emotional, physical, and social impact of this disease. This review discusses some of the options available to clinicians worldwide under the broad headings of chemoprevention and dietary modification including lifestyle issues. From the review of available literature, it is appreciated that although many exciting options such as androgen inhibitors, vitamin E, and selenium are being actively considered, they are far from being included in clinical practice. So until large randomized trials confirm the benefit of chemopreventives and dietary modifications, patients may be advised to pursue a diet and lifestyle that ensures overall fitness.

Key Words: prostate cancer • chemoprevention • diet • lifestyle


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